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KMID : 0869120000020010020
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기초간호자연과학회지
2000 Volume.2 No. 1 p.20 ~ p.33
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Histological changes on the renal glomeruli by the Streptozotocin and Alloxan-induced diabetic mouse
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나현주/Hyun Ju Na
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Abstract
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The author was used for the ICR mouse and induced diabetes with the streptozotocin(50㎎/㎏)and allozan(40㎎/㎏). After the testing and the identifying the diabetes, the histological changes of the glomerulus, blood test for the values of blood
sugar,
and urine test for the values of urine protein were investgated. The results are as follows : 1. The values of high blood sugar appeared from the 2 group were about 378㎎/㎗∼709㎎/㎗, in the treated groups with the streptozotocin and alloxan.
The
glycosuria were obviouslyb continued from the 2 weeks to the 12 weeks of the streptozotocin and the alloxan treated groups and the proteinuria was ±∼+ in the 4 weeks and 8 weeks of streptozotocin treated group and were The ketonuria were
generally
negative. 2. In the view of the light microscope, there was no significant histological changes until the 8 weeks. However, in the 12 weeks group treated with the streptozotocin, the mesangial matrix of glomerulus increased Bowman's capsules
adhered to
each other and changed them to the crescence shapes because of increasing the exothelial cells.
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KEYWORD
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